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主营:标记和未标记标准的合成,中间体的合成,代谢物合成
℡ 4000-520-616
℡ 4000-520-616
Medica Lisotopes/Simvastatin/5 mg/4893-5 mg
产品编号:4893-5mg
市  场 价:¥19800.00
场      地:美国(厂家直采)
产品分类: 蛋白类>聚合物>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$990.00
品      牌: Medica Lisotopes
公      司:Medical Isotopes, Inc.
公司分类:
Medica Lisotopes/Simvastatin/5 mg/4893-5 mg
商品介绍
Product:Simvastatin
Catalog Number:4893
CAS Number:79902-63-9
Synonyms:2,2-Dimethylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl -8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester;
(+)-Simvastatin; Cholestat; Lipex; Novo-Simvastatin; Simvotin; Sinvacor; Statin; Zocor; Zorced
Pricing:
5 mg=$990(In Stock)
25 mg=$1,500(In Stock)
Formula:C25H38O5
Molecular Weight:418.57
Structure:Simvastatin
Appearance:White powder
Category:API Compounds
Stability:Stable under recommended storage conditions.
Storage:

Store as supplied, at -20° C for up to 1 year. Store solutions at -20° C for up to 3 months

Transportation:

Non-hazardous for transport

Literature References:

Nègre-Aminou, P., et al. 1997. Biochim. Biophys. Acta. 1345: 259-268. PMID: 9150246;Wójcik, C., et al. 2000. Int. J. Biochem. Cell Biol. 32: 957-965. PMID: 11084375;Danesh, F.R., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 8301-8305. PMID: 12048257;Blanco-Colio, L.M., et al. 2003. Kidney Int. 63: 12-23. PMID: 12472764;Chopra, V., et al. 2007. Cardiovasc Drugs Ther. 21: 161-169. PMID: 17468937;Wang, H., et al. 2007. Exp. Neurol. 206: 59-69. PMID: 17521631

MSDS:
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Description:

Simvastatin is an 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho GTPase/p21 signaling in mesangial cells

Applications:

A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic

品牌介绍

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