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主营:标记和未标记标准的合成,中间体的合成,代谢物合成
℡ 4000-520-616
℡ 4000-520-616
Medica Lisotopes/Chlorambucil/5 mg/17416-5 mg
产品编号:17416-5mg
市  场 价:¥13800.00
场      地:美国(厂家直采)
产品分类: 蛋白类>聚合物>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$690.00
品      牌: Medica Lisotopes
公      司:Medical Isotopes, Inc.
公司分类:
Medica Lisotopes/Chlorambucil/5 mg/17416-5 mg
商品介绍
Product:Chlorambucil
Catalog Number:17416
CAS Number:305-03-3
Synonyms:4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid;
4-[Bis(2-chloroethyl)amino]benzenebutyric acid
Pricing:
5 mg=$690
50 mg=$990
Formula:C14H19Cl2NO2
Molecular Weight:304.21
Structure:Chlorambucil
Appearance:Beige powder
Category:Anti-cancer compounds
Stability:Stable under recommended storage conditions.
Storage:

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C.

Transportation:

IATA: Hazard Class: 6.1; UN Number: UN2811; Packing Group: III; Shipping Name: Toxic solids, organic, n.o.s. (Chlorambucil)

Literature References:

Muller, C., et al., DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. Blood 92, 2213-2219, (1998); Morrow, C.S., et al., Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. J. Biol. Chem. 273, 20114-20120, (1998); Morabito, F., et al., Bcl-2 protein expression and p53 gene mutation in chronic lymphocytic leukemia: correlation with in vitro sensitivity to chlorambucil and purine analogs. Haematologica 82, 16-20, (1997); Panasci, L., et al., Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repair. Clin. Cancer Res. 7, 454-461, (2001); Merck 14,2073; Beil. 14,IV,1715

MSDS:
Description:

Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. Death of chronic lymphocytic leukemia cells occurs via a p53-dependent mechanism

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